Final Fantasy XV: something about the brotherhood of it all, and I bawled at the scene of Noctis sacrificing himself. Killed me.
Ocarina of Time: The fact that your childhood was basically stolen from you and then given back to you. As a kid, I cried, even though I didn't understand this. Like, this came when I was 10. And I felt too young, if that makes sense. Like I just wanted to grow up already. I didn't see the point of Link giving up his badass adult body and the Master Sword just to go back to Kokiri or find Termina or whatever. But I still cried because I think I connected with it in more of a spiritual way, I guess? Like I couldn't understand it, but I did at the same time. The end scene where all of the NPC's just chill out is also a happy-tearjerker.
Sonic Frontiers: Game sucked, story mostly boring, but the vocal performances from Mike Pollock and Ryan Bartley really got to me.
Overwatch: Dunno if this counts, but all the shorts are either cool as hell or absolutely devastating emotionally.
The Last of Us, basically the whole game
Mega Man X3: End credits and cast roll music were beautiful.
Sonic Generations: I have bittersweet memories of my IRL experience with this game.
DDLC: Even watching this game through the lens of Game Grumps, who gave silly voices to the characters and made jokes a minute...the scene where you stay at school the whole weekend is just, like, the worst thing I've seen in my life.